Hemp Extract(CBD) is a non-intoxicating1 type of substance known as a cannabinoid. Cannabinoids are active compounds mainly found within the cannabis genus of plants, which includes the commonly-identified “species” cannabis sativa and cannabis indica (the classification of cannabis species and sub-species is highly disputed)1. Toward the end of the 1980s, an animal study revealed a specific biological signaling system for these compounds2; now known as the endocannabinoid system (ECS), it is seemingly involved in an “ever-increasing” number of pathological conditions.3
The discovery and subsequent study of the ECS revealed cannabinoid-type compounds produced endogenously (that is, within the body), which are active in the ECS; the endogenous cannabinoid anandamide (AEA) was discovered in 19924, and the ECS activity of a compound called 2-arachidonoylglycerol (2-AG) was discovered in 1994-1995.2 These primary ECS compounds, and others of the same type discovered since, are now accordingly called endocannabinoids.
The ECS, in broad terms, consists of: endocannabinoids, the receptors they (and other exogenous cannabinoids such as those found in cannabis) bind to in order to perform various biological functions, and the enzymes that synthesize and degrade the endocannabinoids. The two mainly-identified ECS receptors are the CB1 and CB2 receptors, which are primarily located in nerve cells (neurons) and immune cells, respectively.5However, the CB1 receptor has been shown to exist in many peripheral organs and tissues, including the skin, heart, lungs, blood vessels and more, in addition to the CNS (central nervous system)6, while the CB2 receptor has been located in CNS neurons.5
So where does Hemp Extract fit into all of this? In short, the expression (concentration) of the ECS receptors (and other receptors) in various regions of the body (including those affected by an adverse condition such as inflammation or a tumor) can potentially indicate a role of compounds which affect those receptors in the stable functioning of the healthy areas, or in the relief of conditions plaguing adversely affected ones. CBD is a complex molecule in that it has been found to utilize many bodily mechanisms, both inside and outside of the ECS.
Inside the ECS, for example, while Hemp Extract has low binding affinity for (does not bind strongly to) the ECS receptors7, it has been shown to indirectly affect them by inhibiting the enzyme responsible for breaking down anandamide.8 One study9 shows anandamide to inhibit the spreading of breast cancer cells, and discusses how it also performs many other biological functions according to other research: lowering of cardiovascular and ocular (eye) blood pressure, lowering of heart rate, inhibition of contractions of smooth muscles in the gastrointestinal and urinary system, modulation of uterus-embryo interactions during pregnancy, and various immune responses. Outside the ECS, for example, one study10shows that CBD activates 5-HT1A receptors in the brain, reducing the behavioural and cardiovascular response to acute restraint stress in rats, and further suggests potential in stress-coping mechanisms related to psychiatric conditions such as depression and post-traumatic stress disorder (PTSD).
As a consequence of all this, these many complex mechanisms must be considered in the scope of medical research surrounding CBD, despite the immense therapeutic potential demonstrated for a wide range of conditions. Unfortunately, these are complicated matters not typically understood by the everyday individual to be able to voice a need to investigate this potential. These scientific barriers, as well as political barriers built by the controversy surrounding cannabis, are no doubt mostly responsible for the “slow” progress of research. It is our hope that we can help build a well-informed community with a voice, to be able to break these barriers and steadily move CBD into the forefront of medical investigations.
- Dufresnes C, Jan C, Bienert F, Goudet J, Fumagalli L. Broad-scale genetic diversity of cannabis for forensic applications. PLoS ONE 2017;12.1: e0170522. doi:10.1371/journal.pone.0170522
- Gyires K, Zádori ZS. Role of cannabinoids in gastrointestinal mucosal defense and inflammation. Curr Neuropharmacol. 2016;14(8):935-951. doi:10.2174/1570159X14666160303110150.
- 2. Di Marzo V, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004;3:771-784. doi:10.1038/nrd1495
- Devane WA, Hanus L, Breuer A, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992;258.5090: 1946-1949. doi:10.1126/science.1470919
- Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153(2):199-215. doi:10.1038/sj.bjp.0707442.
- Grotenhermen F, Müller-Vahl K. The therapeutic potential of cannabis and cannabinoids.Dtsch Arztebl Int. 2012;109(29-30):495-501. doi:10.3238/arztebl.2012.0495.
- Thomas BF, Gilliam AF, Burch DF, Roche MJ, Seltzman HH. Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther. 1998;285(1):285-292. http://jpet.aspetjournals.org/content/285/1/285.long
- Bisogno T, Hanuš L, De Petrocellis L, et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001;134(4):845-852. doi:10.1038/sj.bjp.0704327.
- De Petrocellis L, Melck D, Palmisano A, et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci U S A. 1998;95(14):8375-8380. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20983/
- Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol. 2009;156(1):181-188. doi:10.1111/j.1476-5381.2008.00046.x.